Biotin and derivatives
Medchemexpress LLC DBCO-NHCO-S-S-NHS ester | 96.0% | 565.66 | C28H27N3O6S2 | 25 MG
DBCO-NHCO-S-S-NHS ester is a cleavable antibody-drug conjugate (ADC) linker and click-chemistry reagent containing a DBCO moiety. It is designed to couple to amines via the NHS ester and to react with azide-bearing molecules through strain-promoted alkyne-azide cycloaddition (SPAAC); the disulfide (S-S) bond provides a reducible, cleavable linker for payload release.
- cleavable disulfide linker for reductive release
- n-hydroxysuccinimide (nhs) ester for amine coupling
- dbco group enables copper-free spaac click chemistry with azides
- solid, white to off-white appearance for easy handling
- available in small research pack sizes (including 25 mg)
- storage: powder at -20°C; in solvent stability at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC Mal-PEG12-NHS ester | 2669737-09-9 | MFCD31811553 | 97.0% | C35H58N2O18 | 10MG
Mal-PEG12-NHS ester is a heterobifunctional PEG12 linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. It enables efficient, site-selective conjugation of sulfhydryl-containing molecules to primary amines through a hydrophilic PEG12 spacer, and is commonly used in PROTAC synthesis and general bioconjugation workflows. Molecular weight ≈794.84 g·mol⁻¹; CAS 2669737-09-9; typical purity ≈97%.
- Heterobifunctional maleimide-NHS chemistry for thiol-to-amine conjugation.
- PEG12 spacer increases solubility and reduces steric hindrance.
- Suitable for PROTAC linker synthesis and general bioconjugation.
- High purity (~97%) for reliable analytical and preparative use.
- Available in small-scale quantities for research applications.
Medchemexpress LLC PD-L1 Human Biotin 20ug
Recombinant, biotinylated human PD-L1 produced in HEK293 cells and supplied as a lyophilized 20 μg vial for research use. The protein includes C-terminal human Fc and Avi tags, is characterized for purity and molecular mass, and exhibits specific binding activity suitable for PD-1/PD-L1 interaction and immunoassay applications.
- Expressed in HEK293 mammalian cells.
- Contains C-terminal human Fc and Avi tags.
- Site-specific biotinylation via Avi tag.
- Purity greater than 95% by reducing SDS-PAGE.
- Lyophilized from 20 mM PB, 150 mM NaCl, pH 7.4.
- Predicted molecular mass 54.2 kDa; apparent 70-95 kDa by SDS-PAGE.
- Demonstrated binding activity with ED50 of 15.30 ng/mL.
- Store frozen and aliquot after reconstitution for long-term stability.
Medchemexpress LLC Pomalidomide-C3-NHS ester | 2828476-87-3 | 98.7% | 456.41 | 50 MG
Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Includes NHS ester linker
- Stable under recommended storage conditions
- Ships at room temperature in continental US
- Stores at 4°C, sealed, away from moisture
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC Biotin LC hydrazide | 109276-34-8 | MFCD00077659 | 99.8% | 371.50 g/mol | C16H29N5O3S | 50 MG
Biotin LC hydrazide is a long-chain hydrazide reagent used to introduce a biotin tag onto periodate-oxidized glycans and glycoproteins. It labels aldehyde groups created by mild oxidation, delivering a biotin tag with an extended spacer arm that improves accessibility for detection and capture in downstream assays.
- Reacts with periodate-oxidized glycoproteins and carbohydrate aldehydes.
- Provides an extended spacer arm for improved streptavidin accessibility.
- Suitable for biotinylation of proteins, glycans, and nucleic acids.
- High purity suitable for analytical and preparative applications.
- Provided as a solid in small, research-scale quantities.
Medchemexpress LLC NSP-SA-NHS | 199293-83-9 | 99.7% | 25 MG
NSP-SA-NHS is an acridinium ester designed for chemiluminescent immunoassay. It enables the development of rapid and sensitive immunoassays, such as for Bisphenol A (BPA) detection.
- Can be used for chemiluminescent immunoassay.
- A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed.
Medchemexpress LLC N-piperidine Ibrutinib hydrochloride | 2231747-18-3 | 98.1% | 50 MG
N-piperidine Ibrutinib hydrochloride is a reversible Ibrutinib derivative and a potent BTK inhibitor. It can be used as a BTK ligand in the synthesis of various PROTACs.
- Potent BTK inhibitor with IC50s of 51.0 nM for WT BTK and 30.7 nM for C481S BTK.
- Can be used as a BTK ligand in the synthesis of PROTACs.
- Enables synthesis of potent PROTAC BTK degraders.
Medchemexpress LLC m-PEG-NHS ester | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 250 MG
m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein, thereby leveraging the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Targets PROTAC linkers
- Exploits the intracellular ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
Medchemexpress LLC 3H-indolium inner salt (TEA), N-hydroxysuccinimide ester | 1620475-28-6 | 95.0% | 1043.25 | C45H62N4O16S4 | 10 MG
Alexa Fluor 647 NHS ester (TEA) is a far-red, photostable succinimidyl ester dye supplied as the triethylammonium (TEA) salt for covalent labeling of primary amines on proteins, peptides, and amine-modified oligonucleotides. It produces strong fluorescence suitable for fluorescence imaging, flow cytometry, and other fluorescence-based assays. The product is supplied as a blue to dark blue solid and is sensitive to moisture and light.
- Reactive succinimidyl ester for covalent labeling of primary amines.
- Far-red fluorescence compatible with 633-647 nm excitation for imaging and flow cytometry.
- Photostable with high signal intensity for prolonged imaging.
- Suitable for labeling proteins, peptides, and amine-modified oligonucleotides.
- Supplied as a blue to dark blue solid in TEA salt form; store sealed, away from moisture and light.
Sigma Aldrich Fine Chemicals Biosciences Biotin | 58-85-5 | MFCD00005541 | 5 g
Biotin | Purity: 99% | Mol Wt: 244.31 | 58-85-5 | MFCD00005541 | 5 g
Medchemexpress LLC Biotin N-hydroxysuccinimide ester | 35013-72-0 | 99.9% | 200 MG
Biotin NHS is an amino reactive biotin reagent utilized in the preparation of biotinylated surfaces or polypeptides. It can function as a chemical label for polypeptides and nanocarriers, and is also suitable for labeling biotinylated viruses. This compound is unstable in solutions, therefore freshly prepared solutions are recommended for optimal results.
- Amino reactive biotin reagent
- Can be used as a chemical label for polypeptide and nanocarrier
- Suitable for labeling biotinylated virus
Medchemexpress LLC Biotin-DADOO (Biotinyl-3,6-dioxaoctanediamine) | 138529-46-1 | 98.0% | 500 MG
Biotin-DADOO is a biotin-containing amine compound and a biotinylation reagent. It acts as an amino component in the nucleophilic ring-opening reaction of epoxidized ω-double bonds during the synthesis of biotinylated inhibitor derivatives. This product can be conjugated with carboxymethyl cellulose derivatives and is involved in the synthesis of biotin-estradiol conjugates for enzyme immunoassays. It can also be utilized in influenza A research.
- Captures free influenza neuraminidase on streptavidin-coated polystyrene plates.
- Forms stable self-assembled monolayers (SAMs) on planar gold surfaces.
- Forms a stable biotin-estradiol conjugate.
Medchemexpress LLC Biotin-DADOO TFA | 194920-57-5 | 95.0% | 250 MG
Biotin-DADOO TFA is a biotinylating reagent that is conjugated to CMC thiosulfate.
- Can be utilized to synthesize biotin-estradiol conjugates.
- Used for the determination of plasma estradiol concentrations by enzyme immunoassay.
- Appearance: oil.
- Color: light yellow to brown.
- For research use only.
TARGETMOL CHEMICALS INC Cy3 NHS ester 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Cy3 NHS ester is a fluorescent dye used to label amino groups in proteins, peptides, antibodies, and oligonucleotides. The excitation/emission (Ex/Em) values of Cy3 NHS ester are 550 nm/570 nm. Purity 98.03%
Medchemexpress LLC TCO-PEG12-NHS ester | 2185016-39-9 | MFCD00012569 | 95.0% | 866.99 | C40H70N2O18 | 10 MG
TCO-PEG12-NHS ester is a PEG-based linker reagent consisting of a trans-cyclooctene (TCO) group connected through a 12-unit polyethylene glycol (PEG12) spacer to an N-hydroxysuccinimide (NHS) ester. It enables efficient amine coupling and rapid tetrazine click chemistry, and is used as a cleavable linker in ADC and PROTAC synthesis for bioconjugation applications.
- Provides a TCO functional group for rapid click reactions.
- PEG12 spacer improves solubility and reduces steric hindrance.
- NHS ester enables efficient coupling to primary amines.
- Suitable for ADC and PROTAC linker construction and general bioconjugation.
- Supplied in small research-scale quantities for conjugation workflows.